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Modeling the structural and dynamical changes of the epithelial calcium channel TRPV5 caused by the A563T variation based on the structure of TRPV6

TRPV5 is an epithelial Ca(2+) channel that plays a key role in the active Ca(2+) reabsorption process in the kidney. A single nucleotide polymorphism (SNP) rs4252499 in the TRPV5 gene results in an A563T variation in the sixth transmembrane (TM) domain of TRPV5. Our previous study indicated that thi...

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Bibliographische Detailangaben
Veröffentlicht in:J Biomol Struct Dyn
Hauptverfasser: Wang, Lingyun, Holmes, Ross P., Peng, Ji-Bin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397782/
https://ncbi.nlm.nih.gov/pubmed/30175942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/07391102.2018.1518790
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