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Blockade of muscarinic acetylcholine receptors facilitates motivated behaviour and rescues a model of antipsychotic-induced amotivation

Disruptions to motivated behaviour are a highly prevalent and severe symptom in a number of neuropsychiatric and neurodegenerative disorders. Current treatment options for these disorders have little or no effect upon motivational impairments. We assessed the contribution of muscarinic acetylcholine...

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Pubblicato in:Neuropsychopharmacology
Autori principali: Hailwood, Jonathan M., Heath, Christopher J., Phillips, Benjamin U., Robbins, Trevor W., Saksida, Lisa M., Bussey, Timothy J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer International Publishing 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397643/
https://ncbi.nlm.nih.gov/pubmed/30478410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-018-0281-8
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