Estrogen but not testosterone preserves myofilament function from doxorubicin-induced cardiotoxicity by reducing oxidative modifications

Here, we aimed to explore sex differences and the impact of sex hormones on cardiac contractile properties in doxorubicin (DOX)-induced cardiotoxicity. Male and female Sprague-Dawley rats were subjected to sham surgery or gonadectomy and then treated or untreated with DOX (2 mg/kg) every other week...

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Bibliografske podrobnosti
izdano v:Am J Physiol Heart Circ Physiol
Main Authors: Rattanasopa, Chutima, Kirk, Jonathan A., Bupha-Intr, Tepmanas, Papadaki, Maria, de Tombe, Pieter P., Wattanapermpool, Jonggonnee
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2019
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397386/
https://ncbi.nlm.nih.gov/pubmed/30499711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00428.2018
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