Palladium based nanoparticles for the treatment of advanced melanoma

IGF1R and CD44 are overexpressed in most advanced melanomas so we designed chemotherapeutic nanoparticles to target those receptors. Tris(dibenzylideneacetone)dipalladium (Tris DBA-Pd) is a novel inhibitor of N-myristoyltransferase 1 (NMT-1) and has proven in vivo activity against melanoma. However,...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Elsey, Justin, Bubley, Jeffrey A., Zhu, Lei, Rao, Shikha, Sasaki, Maiko, Pollack, Brian P., Yang, Lily, Arbiser, Jack L.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397149/
https://ncbi.nlm.nih.gov/pubmed/30824801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40258-6
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