Dual inhibition of MEK and p38 impairs tumor growth in KRAS-mutated non-small cell lung cancer

Despite the high frequency of KRAS mutations in non-small cell lung cancer (NSCLC), therapeutic modalities targeting KRAS-mutated NSCLC have not been established. Based on our previous findings that mutant KRAS knockdown sensitized NSCLC cells to a p38 inhibitor, the growth-inhibitory effect of dual...

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Pubblicato in:Oncol Lett
Autori principali: Sunaga, Noriaki, Miura, Yosuke, Tsukagoshi, Yusuke, Kasahara, Norimitsu, Masuda, Tomomi, Sakurai, Reiko, Kaira, Kyoichi, Hisada, Takeshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: D.A. Spandidos 2019
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6396226/
https://ncbi.nlm.nih.gov/pubmed/30867799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2019.10009
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