Bone and Joint Tissue Penetration of the Staphylococcus-Selective Antibiotic Afabicin in Patients Undergoing Elective Hip Replacement Surgery

Afabicin (formerly Debio 1450, AFN-1720) is a prodrug of afabicin desphosphono (Debio 1452, AFN-1252), a novel antibiotic in development which targets the staphylococcal enoyl-acyl carrier protein reductase (FabI) and exhibits selective potent antibacterial activity against staphylococcal species, i...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Menetrey, Annick, Janin, Annick, Pullman, John, Overcash, J. Scott, Haouala, Amina, Leylavergne, François, Turbe, Laurent, Wittke, Frederick, Nicolas-Métral, Valérie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Clinical Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6395911/
https://ncbi.nlm.nih.gov/pubmed/30559136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01669-18
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