Modeling ErbB2-p130Cas interaction to design new potential anticancer agents

The ErbB2 receptor tyrosine kinase is overexpressed in approximately 15–20% of breast tumors and associated with aggressive disease and poor clinical outcome. p130Cas represents a nodal scaffold protein regulating cell survival, migration and proliferation in normal and pathological contexts. p130Ca...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Costamagna, Andrea, Rossi Sebastiano, Matteo, Natalini, Dora, Simoni, Matilde, Valabrega, Giorgio, Defilippi, Paola, Visentin, Sonja, Ermondi, Giuseppe, Turco, Emilia, Caron, Giulia, Cabodi, Sara
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6395809/
https://ncbi.nlm.nih.gov/pubmed/30816273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-39510-w
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