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Modeling ErbB2-p130Cas interaction to design new potential anticancer agents
The ErbB2 receptor tyrosine kinase is overexpressed in approximately 15–20% of breast tumors and associated with aggressive disease and poor clinical outcome. p130Cas represents a nodal scaffold protein regulating cell survival, migration and proliferation in normal and pathological contexts. p130Ca...
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| Опубликовано в: : | Sci Rep |
|---|---|
| Главные авторы: | , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6395809/ https://ncbi.nlm.nih.gov/pubmed/30816273 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-39510-w |
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