Modulation by Sigma-1 Receptor of Morphine Analgesia and Tolerance: Nociceptive Pain, Tactile Allodynia and Grip Strength Deficits During Joint Inflammation

Sigma-1 receptor antagonism increases the effects of morphine on nociceptive pain, even in morphine-tolerant animals. However, it is unknown whether these receptors are able to modulate morphine antinociception and tolerance during inflammatory pain. Here we used a mouse model to test the modulation...

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Montilla-García, Ángeles, Tejada, Miguel Á., Ruiz-Cantero, M. Carmen, Bravo-Caparrós, Inmaculada, Yeste, Sandra, Zamanillo, Daniel, Cobos, Enrique J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6395397/
https://ncbi.nlm.nih.gov/pubmed/30853912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00136
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