Serum vascular endothelial growth factor-D as a diagnostic and therapeutic biomarker for lymphangioleiomyomatosis

BACKGROUND: In lymphangioleiomyomatosis (LAM), tuberous sclerosis gene mutations activate the mechanistic target of the rapamycin pathway, resulting in vascular endothelial growth factor-D (VEGF-D) overproduction. While the utility of serum VEGF-D testing for the diagnosis of LAM is outlined in ATS/...

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Udgivet i:PLoS One
Main Authors: Hirose, Masaki, Matsumuro, Akiko, Arai, Toru, Sugimoto, Chikatoshi, Akira, Masanori, Kitaichi, Masanori, Young, Lisa R., McCormack, Francis X., Inoue, Yoshikazu
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6395035/
https://ncbi.nlm.nih.gov/pubmed/30818375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0212776
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