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Clustering of temporal gene expression data with mixtures of mixed effects models with a penalized likelihood

MOTIVATION: Clustering algorithms like K-Means and standard Gaussian mixture models (GMM) fail to account for the structure of variability of replicated data or repeated measures over time. Additionally, a priori cluster number assumptions add an additional complexity to the process. Current methods...

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Publicat a:Bioinformatics
Autors principals: Lu, Darlene, Tripodis, Yorghos, Gerstenfeld, Louis C, Demissie, Serkalem
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6394398/
https://ncbi.nlm.nih.gov/pubmed/30101356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/bty696
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