Endoplasmic Reticulum Stress Induces Macrophages to Produce IL-1β During Mycobacterium bovis Infection via a Positive Feedback Loop Between Mitochondrial Damage and Inflammasome Activation

Mycobacterium bovis, the causative agent of tuberculosis in cattle and humans, infects host macrophages and induces endoplasmic reticulum stress (ERS), mitochondrial damage, and interleukin (IL)-1β production. The relationship between these phenotypes is yet to be elucidated. In this study, we inves...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Liao, Yi, Hussain, Tariq, Liu, Chunfa, Cui, Yongyong, Wang, Jie, Yao, Jiao, Chen, Hehua, Song, Yinjuan, Sabir, Naveed, Hussain, Mazhar, Zhao, Deming, Zhou, Xiangmei
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6394253/
https://ncbi.nlm.nih.gov/pubmed/30846986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00268
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