Combined administration of anti-IL-13 and anti-IL-17A at individually sub-therapeutic doses limits asthma-like symptoms in a mouse model of Th2/Th17 high asthma

BACKGROUND: Recent studies have demonstrated that Th2 responses have the ability to antagonize Th17 responses. In mouse models of allergic asthma, blockade of Th2-effector cytokines results in elaboration of Th17 responses and associated increases in pulmonary neutrophilia. While these can be contro...

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Pubblicato in:Clin Exp Allergy
Autori principali: Kim, Dasom, McAlees, Jaclyn W., Bischoff, Lindsay J., Kaur, Davinder, Houshel, Lauren K., Gray, Jerilyn, Hargis, Julie, Davis, Xenia, Dudas, Paul L., Deshmukh, Hitesh, Lewkowich, Ian P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6393183/
https://ncbi.nlm.nih.gov/pubmed/30353972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cea.13301
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