Loss of ABHD15 Impairs the Anti-lipolytic Action of Insulin by Altering PDE3B Stability and Contributes to Insulin Resistance

Elevated circulating fatty acids (FAs) contribute to obesity-associated metabolic complications, but the mechanisms by which insulin suppresses lipolysis are poorly understood. We show that α/β-hydrolase domain-containing 15 (ABHD15) is required for the anti-lipolytic action of insulin in white adip...

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Publicado no:Cell Rep
Main Authors: Xia, Wenmin, Pessentheiner, Ariane R., Hofer, Dina C., Amor, Melina, Schreiber, Renate, Schoiswohl, Gabriele, Eichmann, Thomas O., Walenta, Evelyn, Itariu, Bianca, Prager, Gerhard, Hackl, Hubert, Stulnig, Thomas, Kratky, Dagmar, Rülicke, Thomas, Bogner-Strauss, Juliane G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6390945/
https://ncbi.nlm.nih.gov/pubmed/29768196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.04.055
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