Human 3D Gastrointestinal Microtissue Barrier Function As a Predictor of Drug-Induced Diarrhea

Drug-induced gastrointestinal toxicities (GITs) rank among the most common clinical side effects. Preclinical efforts to reduce incidence are limited by inadequate predictivity of in vitro assays. Recent breakthroughs in in vitro culture methods support intestinal stem cell maintenance and continual...

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Udgivet i:Toxicol Sci
Main Authors: Peters, Matthew F, Landry, Tim, Pin, Carmen, Maratea, Kim, Dick, Cortni, Wagoner, Matthew P, Choy, Allison L, Barthlow, Herb, Snow, Deb, Stevens, Zachary, Armento, Alex, Scott, Clay W, Ayehunie, Seyoum
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
3d GI Models for Predicting Drug-Induced Diarrhea
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6390652/
https://ncbi.nlm.nih.gov/pubmed/30364994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy268
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