Genetic inactivation of hypoxia inducible factor 1-alpha (HIF-1α) in adult hippocampal progenitors impairs neurogenesis and pattern discrimination learning

HIF-1α is a hypoxia-inducible protein that regulates many cellular processes, including neural stem cell maintenance. Previous work demonstrated constitutive stabilization of HIF-1α in neural stem cells (NSCs) of the adult mouse subventricular zone (SVZ) and hippocampal subgranular zone (SGZ). Genet...

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Bibliografiske detaljer
Udgivet i:Neurobiol Learn Mem
Main Authors: Carrica, Lauren, Li, Lu, Newville, Jessie, Kenton, Johnny, Gustus, Kymberly, Brigman, Jonathan, Cunningham, Lee Anna
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6389421/
https://ncbi.nlm.nih.gov/pubmed/30521851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nlm.2018.12.002
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