Biomechanical changes to Descemet’s membrane precede endothelial cell loss in an early-onset murine model of Fuchs endothelial corneal dystrophy

Early-onset Fuchs endothelial corneal dystrophy (FECD) has been associated with nonsynonymous mutations in collagen VIII α2 (COL8A2), a key extracellular matrix (ECM) protein in Descemet’s membrane (DM). Two knock-in strains of mice have been generated to each express a mutant COL8A2 protein (Col8a2...

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Publicado en:Exp Eye Res
Main Authors: Leonard, Brian C., Jalilian, Iman, Raghunathan, Vijay Krishna, Wang, Wei, Jun, Albert S., Murphy, Christopher J., Thomasy, Sara M.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6389414/
https://ncbi.nlm.nih.gov/pubmed/30471280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2018.11.021
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