Increased gene copy number of DEFA1/DEFA3 worsens sepsis by inducing endothelial pyroptosis

Sepsis claims an estimated 30 million episodes and 6 million deaths per year, and treatment options are rather limited. Human neutrophil peptides 1–3 (HNP1–3) are the most abundant neutrophil granule proteins but their neutrophil content varies because of unusually extensive gene copy number polymor...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Chen, QiXing, Yang, Yang, Hou, JinChao, Shu, Qiang, Yin, YiXuan, Fu, WeiTao, Han, Feng, Hou, TingJun, Zeng, CongLi, Nemeth, Elizabeta, Linzmeier, Rose, Ganz, Tomas, Fang, XiangMing
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6386704/
https://ncbi.nlm.nih.gov/pubmed/30718392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1812947116
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