A potential key mechanism in ascending aortic aneurysm development: Detection of a linear relationship between MMP-14/TIMP-2 ratio and active MMP-2

OBJECTIVES: Elevated matrix metalloproteinase-2 (MMP-2) tissue levels have been associated with ascending thoracic aortic aneurysm (aTAA). As MMP-2 activation is controlled by interactions among matrix metalloproteinase-14 (MMP-14), a tissue inhibitor of metalloproteinases-2 (TIMP-2) and Pro-MMP-2 i...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Schmitt, Ramona, Tscheuschler, Anke, Laschinski, Philipp, Uffelmann, Xenia, Discher, Philipp, Fuchs, Jana, Kreibich, Maximilian, Peyronnet, Remi, Kari, Fabian A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6386481/
https://ncbi.nlm.nih.gov/pubmed/30794673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0212859
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