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Efficient synthesis of chiral 2,3-dihydro-benzo[b]thiophene 1,1-dioxides via Rh-catalyzed hydrogenation

Rh-catalyzed asymmetric hydrogenation of prochiral substituted benzo[b]thiophene 1,1-dioxides was successfully developed, affording various chiral 2,3-dihydrobenzo[b]thiophene 1,1-dioxides with high yields and excellent enantioselectivities (up to 99% yield and >99% ee). In particular, for challe...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Liu, Gongyi, Zhang, Heng, Huang, Yi, Han, Zhengyu, Liu, Gang, Liu, Yuanhua, Dong, Xiu-Qin, Zhang, Xumu
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6385876/
https://ncbi.nlm.nih.gov/pubmed/30881681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc05397a
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