A platform for glycoengineering a polyvalent pneumococcal bioconjugate vaccine using E. coli as a host

Chemical synthesis of conjugate vaccines, consisting of a polysaccharide linked to a protein, can be technically challenging, and in vivo bacterial conjugations (bioconjugations) have emerged as manufacturing alternatives. Bioconjugation relies upon an oligosaccharyltransferase to attach polysacchar...

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Publicado en:Nat Commun
Main Authors: Harding, Christian M., Nasr, Mohamed A., Scott, Nichollas E., Goyette-Desjardins, Guillaume, Nothaft, Harald, Mayer, Anne E., Chavez, Sthefany M., Huynh, Jeremy P., Kinsella, Rachel L., Szymanski, Christine M., Stallings, Christina L., Segura, Mariela, Feldman, Mario F.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6385209/
https://ncbi.nlm.nih.gov/pubmed/30792408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08869-9
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