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Octa-repeat domain of the mammalian prion protein mRNA forms stable A-helical hairpin structure rather than G-quadruplexes

Misfolding and aggregation of prion protein (PrP) causes neurodegenerative diseases like Creutzfeldt-Jakob disease (CJD) and scrapie. Besides the consensus that spontaneous conversion of normal cellular PrP(C) into misfolded and aggregating PrP(Sc) is the central event in prion disease, an alternati...

詳細記述

保存先:
書誌詳細
出版年:Sci Rep
主要な著者: Czech, Andreas, Konarev, Petr V., Goebel, Ingrid, Svergun, Dmitri I., Wills, Peter R., Ignatova, Zoya
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6384910/
https://ncbi.nlm.nih.gov/pubmed/30792490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-39213-2
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