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Simvastatin prevents articular chondrocyte dedifferentiation induced by nitric oxide by inhibiting the expression of matrix metalloproteinases 1 and 13
In this study, we investigated whether simvastatin (SVT), a statin commonly prescribed to decrease cholesterol levels, might have a therapeutic effect in OA. Primary rabbit chondrocytes were pre-treated with SVT (50 μM), then treated with sodium nitroprusside (SNP; 1 mM), a donor of nitric oxide (NO...
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| Veröffentlicht in: | Exp Biol Med (Maywood) |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
SAGE Publications
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6384441/ https://ncbi.nlm.nih.gov/pubmed/32459510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1535370218820650 |
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