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Genetic Modification Strategies to Enhance CAR T Cell Persistence for Patients With Solid Tumors

Immunotherapy with chimeric antigen receptor (CAR) T cells offers a promising method to improve cure rates and decrease morbidities for patients with cancer. In this regard, CD19-specific CAR T cell therapies have achieved dramatic objective responses for a high percent of patients with CD19-positiv...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: DeRenzo, Christopher, Gottschalk, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6384227/
https://ncbi.nlm.nih.gov/pubmed/30828333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00218
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