Experimental Evolution of Escherichia coli K-12 in the Presence of Proton Motive Force (PMF) Uncoupler Carbonyl Cyanide m-Chlorophenylhydrazone Selects for Mutations Affecting PMF-Driven Drug Efflux Pumps

Experimental evolution of Escherichia coli K-12 with benzoate, a partial uncoupler of the proton motive force (PMF), selects for mutations that decrease antibiotic resistance. We conducted experimental evolution in the presence of carbonyl cyanide m-chlorophenylhydrazone (CCCP), a strong uncoupler....

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Appl Environ Microbiol
Egile Nagusiak: Griffith, Jessie M., Basting, Preston J., Bischof, Katarina M., Wrona, Erintrude P., Kunka, Karina S., Tancredi, Anna C., Moore, Jeremy P., Hyman, Miriam R. L., Slonczewski, Joan L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2019
Gaiak:
Genetics and Molecular Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6384104/
https://ncbi.nlm.nih.gov/pubmed/30578262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.02792-18
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