The PHO signaling pathway directs lipid remodeling in Cryptococcus neoformans via DGTS synthase to recycle phosphate during phosphate deficiency

The phosphate sensing and acquisition (PHO) pathway of Cryptococcus neoformans is essential for growth in phosphate-limiting conditions and for dissemination of infection in a mouse model. Its key transcription factor, Pho4, regulates expression of genes controlling the acquisition of phosphate from...

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Bibliographic Details
Published in:PLoS One
Main Authors: Lev, Sophie, Rupasinghe, Thusitha, Desmarini, Desmarini, Kaufman-Francis, Keren, Sorrell, Tania Christine, Roessner, Ute, Djordjevic, Julianne Teresa
Format: Artigo
Language:Inglês
Published: Public Library of Science 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6383925/
https://ncbi.nlm.nih.gov/pubmed/30789965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0212651
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