Th1 cytokines TNF-α and IFN-γ promote corticosteroid resistance in developing human airway smooth muscle

Corticosteroids (CSs) are commonly used to manage wheezing and asthma in pediatric populations. Although corticosteroids are effective in alleviating airway diseases, some children with more moderate-severe asthma phenotypes show CS resistance and exhibit significant airflow obstruction, persistent...

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Bibliographic Details
Published in:Am J Physiol Lung Cell Mol Physiol
Main Authors: Britt, Rodney D., Thompson, Michael A., Sasse, Sarah, Pabelick, Christina M., Gerber, Anthony N., Prakash, Y. S.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6383501/
https://ncbi.nlm.nih.gov/pubmed/30335498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00547.2017
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