A novel benzamine lead compound of histone deacetylase inhibitor ZINC24469384 can suppresses HepG2 cells proliferation by upregulating NR1H4

Histone deacetylases (HDACs) can enzymatically transferred acetyl functional group from protein or lysine residues of histone, so they can regulate the expression of lots of genes. Now HDACs are used as drug targets and many HDAC inhibitors (HDACis) were approved for cancer therapy or in clinical tr...

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Publicado no:Sci Rep
Main Authors: Song, Qiuhang, Li, Mingyue, Fan, Cong, Liu, Yucui, Zheng, Lihua, Bao, Yongli, Sun, Luguo, Yu, Chunlei, Song, Zhenbo, Sun, Ying, Wang, Guannan, Huang, Yanxin, Li, Yuxin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6382829/
https://ncbi.nlm.nih.gov/pubmed/30787420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-39487-6
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