Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads

Some genetic melanocortin-1 receptor (MC1R) variants responsible for human red hair color (RHC-variants) are consequently associated with increased melanoma risk. Although MC1R signaling is critically dependent on its palmitoylation primarily mediated by the ZDHHC13 protein-acyl transferase, whether...

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Pubblicato in:Nat Commun
Autori principali: Chen, Shuyang, Han, Changpeng, Miao, Xiao, Li, Xin, Yin, Chengqian, Zou, Junrong, Liu, Min, Li, Shanshan, Stawski, Lukasz, Zhu, Bo, Shi, Qiong, Xu, Zhi-Xiang, Li, Chunying, Goding, Colin R., Zhou, Jun, Cui, Rutao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6382811/
https://ncbi.nlm.nih.gov/pubmed/30787281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08691-3
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