Genetic programming of macrophages generates an in vitro model for the human erythroid island niche

Red blood cells mature within the erythroblastic island (EI) niche that consists of specialized macrophages surrounded by differentiating erythroblasts. Here we establish an in vitro system to model the human EI niche using macrophages that are derived from human induced pluripotent stem cells (iPSC...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Lopez-Yrigoyen, Martha, Yang, Cheng-Tao, Fidanza, Antonella, Cassetta, Luca, Taylor, A. Helen, McCahill, Angela, Sellink, Erica, von Lindern, Marieke, van den Akker, Emile, Mountford, Joanne C., Pollard, Jeffrey W., Forrester, Lesley M.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6382809/
https://ncbi.nlm.nih.gov/pubmed/30787325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08705-0
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