The CagRS Two-Component System Regulates Clavulanic Acid Metabolism via Multiple Pathways in Streptomyces clavuligerus F613-1

Streptomyces clavuligerus F613-1 produces a clinically important β-lactamase inhibitor, clavulanic acid (CA). Although the biosynthesis pathway of CA has essentially been elucidated, the global regulatory mechanisms of CA biosynthesis remain unclear. The paired genes cagS and cagR, which are annotat...

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Dettagli Bibliografici
Pubblicato in:Front Microbiol
Autori principali: Fu, Jiafang, Qin, Ronghuo, Zong, Gongli, Liu, Cheng, Kang, Ni, Zhong, Chuanqing, Cao, Guangxiang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
Soggetti:
Microbiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6382702/
https://ncbi.nlm.nih.gov/pubmed/30837970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2019.00244
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