The CagRS Two-Component System Regulates Clavulanic Acid Metabolism via Multiple Pathways in Streptomyces clavuligerus F613-1

Streptomyces clavuligerus F613-1 produces a clinically important β-lactamase inhibitor, clavulanic acid (CA). Although the biosynthesis pathway of CA has essentially been elucidated, the global regulatory mechanisms of CA biosynthesis remain unclear. The paired genes cagS and cagR, which are annotat...

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Publicat a:Front Microbiol
Autors principals: Fu, Jiafang, Qin, Ronghuo, Zong, Gongli, Liu, Cheng, Kang, Ni, Zhong, Chuanqing, Cao, Guangxiang
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019
Matèries:
Microbiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6382702/
https://ncbi.nlm.nih.gov/pubmed/30837970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2019.00244
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