The CagRS Two-Component System Regulates Clavulanic Acid Metabolism via Multiple Pathways in Streptomyces clavuligerus F613-1

Streptomyces clavuligerus F613-1 produces a clinically important β-lactamase inhibitor, clavulanic acid (CA). Although the biosynthesis pathway of CA has essentially been elucidated, the global regulatory mechanisms of CA biosynthesis remain unclear. The paired genes cagS and cagR, which are annotat...

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Bibliographic Details
Published in:Front Microbiol
Main Authors: Fu, Jiafang, Qin, Ronghuo, Zong, Gongli, Liu, Cheng, Kang, Ni, Zhong, Chuanqing, Cao, Guangxiang
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6382702/
https://ncbi.nlm.nih.gov/pubmed/30837970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2019.00244
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