Long-read sequence and assembly of segmental duplications

We developed a computational method based on polyploid phasing of long sequence reads to resolve collapsed regions of segmental duplications within genome assemblies. The approach, Segmental Duplication Assembler (SDA), constructs graphs where paralogous sequence variants define the nodes and long-r...

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Détails bibliographiques
Publié dans:Nat Methods
Auteurs principaux: Vollger, Mitchell R., Dishuck, Philip C., Sorensen, Melanie, Welch, AnneMarie E., Dang, Vy, Dougherty, Max L., Graves-Lindsay, Tina A., Wilson, Richard K., Chaisson, Mark J. P., Eichler, Evan E.
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6382464/
https://ncbi.nlm.nih.gov/pubmed/30559433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41592-018-0236-3
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