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Efficient design and analysis of randomized controlled trials in rare neurological diseases: An example in Guillain-Barré syndrome
BACKGROUND: Randomized controlled trials (RCTs) pose specific challenges in rare and heterogeneous neurological diseases due to the small numbers of patients and heterogeneity in disease course. Two analytical approaches have been proposed to optimally handle these issues in RCTs: covariate adjustme...
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| Udgivet i: | PLoS One |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6382155/ https://ncbi.nlm.nih.gov/pubmed/30785890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0211404 |
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