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Efficient design and analysis of randomized controlled trials in rare neurological diseases: An example in Guillain-Barré syndrome

BACKGROUND: Randomized controlled trials (RCTs) pose specific challenges in rare and heterogeneous neurological diseases due to the small numbers of patients and heterogeneity in disease course. Two analytical approaches have been proposed to optimally handle these issues in RCTs: covariate adjustme...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: van Leeuwen, Nikki, Walgaard, Christa, van Doorn, Pieter A., Jacobs, Bart C., Steyerberg, Ewout W., Lingsma, Hester F.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6382155/
https://ncbi.nlm.nih.gov/pubmed/30785890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0211404
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