The Transcription Factor TCF1 Preserves the Effector Function of Exhausted CD8 T Cells During Chronic Viral Infection

The long-term persistence of viral antigens drives virus-specific CD8 T cell exhaustion during chronic viral infection. Yet exhausted, CD8 T cells are still endowed with certain levels of effector function, by which they can keep viral replication in check in chronic infection. However, the regulato...

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Vydáno v:Front Immunol
Hlavní autoři: Wang, Yifei, Hu, Jianjun, Li, Yiding, Xiao, Minglu, Wang, Haoqiang, Tian, Qin, Li, Zhirong, Tang, Jianfang, Hu, Li, Tan, Yan, Zhou, Xinyuan, He, Ran, Wu, Yuzhang, Ye, Lilin, Yin, Zhinan, Huang, Qizhao, Xu, Lifan
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6381939/
https://ncbi.nlm.nih.gov/pubmed/30814995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00169
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