Identifying Extrinsic versus Intrinsic Drivers of Variation in Cell Behavior in Human iPSC Lines from Healthy Donors

Large cohorts of human induced pluripotent stem cells (iPSCs) from healthy donors are a potentially powerful tool for investigating the relationship between genetic variants and cellular behavior. Here, we integrate high content imaging of cell shape, proliferation, and other phenotypes with gene ex...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Vigilante, Alessandra, Laddach, Anna, Moens, Nathalie, Meleckyte, Ruta, Leha, Andreas, Ghahramani, Arsham, Culley, Oliver J., Kathuria, Annie, Hurling, Chloe, Vickers, Alice, Wiseman, Erika, Tewary, Mukul, Zandstra, Peter W., Durbin, Richard, Fraternali, Franca, Stegle, Oliver, Birney, Ewan, Luscombe, Nicholas M., Danovi, Davide, Watt, Fiona M.
Format: Artigo
Language:Inglês
Published: Cell Press 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6381787/
https://ncbi.nlm.nih.gov/pubmed/30784590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.01.094
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