Pulse Sequence Considerations for Quantification of Pyruvate-to-Lactate Conversion k(PL) in Hyperpolarized (13)C Imaging

Hyperpolarized-(13)C MRI takes advantage of the unprecedented 50,000x SNR enhancement to interrogate cancer metabolism in patients and animals. It can measure the pyruvate-to-lactate conversion rate, k(PL), a metabolic biomarker of cancer aggressiveness and progression. Therefore, it is crucial to e...

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Bibliografiska uppgifter
I publikationen:NMR Biomed
Huvudupphovsmän: Chen, Hsin-Yu, Gordon, Jeremy W., Bok, Robert A., Cao, Peng, von Morze, Cornelius, van Criekinge, Mark, Milshteyn, Eugene, Carvajal, Lucas, Hurd, Ralph E., Kurhanewicz, John, Vigneron, Daniel B., Larson, Peder E.Z.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6380928/
https://ncbi.nlm.nih.gov/pubmed/30664305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/nbm.4052
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