Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter

Poly (ADP-ribose) polymerase 1 (PARP1) has emerged as an attractive target for cancer therapy due to its key role in DNA repair processes. Inhibition of PARP1 in BRCA-mutated cancers has been observed to be clinically beneficial. Recent genome-mapping experiments have identified a non-canonical G-qu...

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Bibliografische gegevens
Gepubliceerd in:Nucleic Acids Res
Hoofdauteurs: Sengar, Anjali, Vandana, J Jeya, Chambers, Vicki S, Di Antonio, Marco, Winnerdy, Fernaldo Richtia, Balasubramanian, Shankar, Phan, Anh Tuân
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2019
Onderwerpen:
Structural Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6379715/
https://ncbi.nlm.nih.gov/pubmed/30551210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1179
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