Significance of urinary C-megalin excretion in vitamin D metabolism in pre-dialysis CKD patients

Serum 1,25(OH)(2)D and 24,25(OH)(2)D are decreased in CKD. Megalin in proximal tubular epithelial cells reabsorbs glomerular-filtered 25(OH)D-DBP complex to convert 25(OH)D to 1,25(OH)(2)D and 24,25(OH)(2)D. Urinary C-megalin excretion is increased via exocytosis from injured nephrons overloaded wit...

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Publicado en:Sci Rep
Main Authors: Toi, Norikazu, Inaba, Masaaki, Ishimura, Eiji, Tsugawa, Naoko, Imanishi, Yasuo, Emoto, Masanori, Hirayama, Yoshiaki, Nakatani, Shinya, Saito, Akihiko, Yamada, Shinsuke
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6379559/
https://ncbi.nlm.nih.gov/pubmed/30778159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-38613-8
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