PBK, targeted by EVI1, promotes metastasis and confers cisplatin resistance through inducing autophagy in high-grade serous ovarian carcinoma

High-grade serous ovarian carcinoma (HGSOC) is the most lethal type of gynecologic malignancy. Chemoresistance is the main reason for the poor prognosis of HGSOC. PDZ-binding kinase (PBK) promotes the malignant progression of various carcinomas. However, the roles and clinical significance of PBK in...

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Veröffentlicht in:Cell Death Dis
Hauptverfasser: Ma, Hanlin, Li, Yingwei, Wang, Xiangxiang, Wu, Huan, Qi, Gonghua, Li, Rongrong, Yang, Ning, Gao, Min, Yan, Shi, Yuan, Cunzhong, Kong, Beihua
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6379381/
https://ncbi.nlm.nih.gov/pubmed/30778048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1415-6
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