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Bullous Pemphigoid IgG Induces Cell Dysfunction and Enhances the Motility of Epidermal Keratinocytes via Rac1/Proteasome Activation

Bullous pemphigoid (BP) is an autoimmune disease characterized by the formation of blisters, in which autoantibodies mainly target type XVII collagen (ColXVII) expressed in basal keratinocytes. BP IgG is known to induce the internalization of ColXVII from the plasma membrane of keratinocytes through...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Tie, Duerna, Da, Xia, Natsuga, Ken, Yamada, Nanako, Yamamoto, Osamu, Morita, Eishin
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6379344/
https://ncbi.nlm.nih.gov/pubmed/30809225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00200
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