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Particle size and gastrointestinal absorption influence tiotropium pharmacokinetics: a pilot bioequivalence study of PUR0200 and Spiriva HandiHaler

AIMS: Plasma pharmacokinetics permit the assessment of efficacy and safety of inhaled drugs, and possibly their bioequivalence to other inhaled products. Correlating drug product attributes to lung deposited dose is important to achieving equivalence. PUR0200 is a spray‐dried formulation of tiotropi...

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Podrobná bibliografie
Vydáno v:Br J Clin Pharmacol
Hlavní autoři: Perry, Jason, Trautman, Brian, Takher‐Smith, Joe, Kramer, Steve, Kane, Katie, Silverman, Michael, Tan, Lisa, Haughie, Scott, Richter, Wolfram, Kirkov, Valentin, Arsova, Sacha, Ward, Jonathan, Hava, David L.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6379222/
https://ncbi.nlm.nih.gov/pubmed/30521129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13831
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