Particle size and gastrointestinal absorption influence tiotropium pharmacokinetics: a pilot bioequivalence study of PUR0200 and Spiriva HandiHaler

AIMS: Plasma pharmacokinetics permit the assessment of efficacy and safety of inhaled drugs, and possibly their bioequivalence to other inhaled products. Correlating drug product attributes to lung deposited dose is important to achieving equivalence. PUR0200 is a spray‐dried formulation of tiotropi...

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書目詳細資料
發表在:Br J Clin Pharmacol
Main Authors: Perry, Jason, Trautman, Brian, Takher‐Smith, Joe, Kramer, Steve, Kane, Katie, Silverman, Michael, Tan, Lisa, Haughie, Scott, Richter, Wolfram, Kirkov, Valentin, Arsova, Sacha, Ward, Jonathan, Hava, David L.
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2019
主題:
Original Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6379222/
https://ncbi.nlm.nih.gov/pubmed/30521129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13831
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