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Statistical assessment and visualization of synergies for large-scale sparse drug combination datasets
BACKGROUND: Drug combinations have the potential to improve efficacy while limiting toxicity. To robustly identify synergistic combinations, high-throughput screens using full dose-response surface are desirable but require an impractical number of data points. Screening of a sparse number of doses...
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Publicado no: | BMC Bioinformatics |
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Main Authors: | , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
BioMed Central
2019
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6378741/ https://ncbi.nlm.nih.gov/pubmed/30777010 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-019-2642-7 |
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