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Statistical assessment and visualization of synergies for large-scale sparse drug combination datasets

BACKGROUND: Drug combinations have the potential to improve efficacy while limiting toxicity. To robustly identify synergistic combinations, high-throughput screens using full dose-response surface are desirable but require an impractical number of data points. Screening of a sparse number of doses...

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Detalhes bibliográficos
Publicado no:BMC Bioinformatics
Main Authors: Amzallag, Arnaud, Ramaswamy, Sridhar, Benes, Cyril H.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6378741/
https://ncbi.nlm.nih.gov/pubmed/30777010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-019-2642-7
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