The rs61742690 (S783N) single nucleotide polymorphism is a suitable target for disrupting BCL11A-mediated foetal-to-adult globin switching

BACKGROUND: B-cell lymphoma/leukaemia 11A (BCL11A) is a C2H2-type zinc-finger transcription factor protein that is a critical modulator of haemoglobin switching and suppresses the production of foetal haemoglobin. Variation in the BCL11A gene ameliorates the severity of sickle cell disease (SCD) and...

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Udgivet i:PLoS One
Main Authors: Abdulazeez, Sayed, Sultana, Shaheen, Almandil, Noor B., Almohazey, Dana, Bency, B. Jesvin, Borgio, J. Francis
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6377191/
https://ncbi.nlm.nih.gov/pubmed/30768627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0212492
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