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Randomized clinical trials with run-in periods: frequency, characteristics and reporting

BACKGROUND: Run-in periods are occasionally used in randomized clinical trials to exclude patients after inclusion, but before randomization. In theory, run-in periods increase the probability of detecting a potential treatment effect, at the cost of possibly affecting external and internal validity...

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Detalhes bibliográficos
Publicado no:Clin Epidemiol
Main Authors: Laursen, David Ruben Teindl, Paludan-Müller, Asger Sand, Hróbjartsson, Asbjørn
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6377048/
https://ncbi.nlm.nih.gov/pubmed/30809104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CLEP.S188752
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