Dexamethasone during pregnancy impairs maternal pancreatic β-cell renewal during lactation

Pancreatic islets from pregnant rats develop a transitory increase in the pancreatic β-cell proliferation rate and mass. Increased apoptosis during early lactation contributes to the rapid reversal of those morphological changes. Exposure to synthetic glucocorticoids during pregnancy has been previo...

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Veröffentlicht in:Endocr Connect
Hauptverfasser: Teixeira, Caio Jordão, Santos-Silva, Junia Carolina, de Souza, Dailson Nogueira, Rafacho, Alex, Anhe, Gabriel Forato, Bordin, Silvana
Format: Artigo
Sprache:Inglês
Veröffentlicht: Bioscientifica Ltd 2019
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6376996/
https://ncbi.nlm.nih.gov/pubmed/30768422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/EC-18-0505
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