Efficient two-step multivariate random effects meta-analysis of individual participant data for longitudinal clinical trials using mixed effects models

BACKGROUND: Mixed effects models have been widely applied in clinical trials that involve longitudinal repeated measurements, which possibly contain missing outcome data. In meta-analysis of individual participant data (IPD) based on these longitudinal studies, joint synthesis of the regression coef...

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Veröffentlicht in:BMC Med Res Methodol
Hauptverfasser: Noma, Hisashi, Maruo, Kazushi, Gosho, Masahiko, Levine, Stephen Z., Goldberg, Yair, Leucht, Stefan, Furukawa, Toshi A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6376708/
https://ncbi.nlm.nih.gov/pubmed/30764757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12874-019-0676-1
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