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Current concepts in osteogenesis imperfecta: bone structure, biomechanics and medical management
The majority of patients with osteogenesis imperfecta (OI) have mutations in the COL1A1 or COL1A2 gene, which has consequences for the composition of the bone matrix and bone architecture. The mutations result in overmodified collagen molecules, thinner collagen fibres and hypermineralization of bon...
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| Publicado no: | J Child Orthop |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The British Editorial Society of Bone & Joint Surgery
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6376438/ https://ncbi.nlm.nih.gov/pubmed/30838070 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1302/1863-2548.13.180190 |
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