HCN as a Mediator of Urinary Homeostasis: Age-Associated Changes in Expression and Function in Adrenergic Detrusor Relaxation

The Hyperpolarization activated, cyclic nucleotide gated (HCN) channel is a candidate mediator of neuroendocrine influence over detrusor tonus during filling. In other tissues, HCN loss with aging is linked to declines in rhythmicity and function. We hypothesized that HCN has an age-sensitive expres...

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Udgivet i:J Gerontol A Biol Sci Med Sci
Main Authors: Al-Naggar, Iman M, Hardy, Cara C, Taweh, Omar G, Grabauskas, Titas, Mulkey, Daniel K, Kuchel, George A, Smith, Phillip P
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
The Journal of Gerontology: Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6376092/
https://ncbi.nlm.nih.gov/pubmed/30124776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/gly137
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