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Nematicidal and insecticidal activities of halogenated indoles

Parasite death via ion channel activations is the hallmark of anthelmintic and antiparasitic drugs. Glutamate gated chloride channel (GluCl) is a prominent targets for drug selection and design in parasitology. We report several iodine-fluorine based lead activators of GluCl by computational studies...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Rajasekharan, Satish Kumar, Lee, Jin-Hyung, Ravichandran, Vinothkannan, Kim, Jin-Cheol, Park, Jae Gyu, Lee, Jintae
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6375993/
https://ncbi.nlm.nih.gov/pubmed/30765810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-38561-3
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