PRMT5 Associates With the FOXP3 Homomer and When Disabled Enhances Targeted p185(erbB2/neu) Tumor Immunotherapy

Regulatory T cells (Tregs) are a subpopulation of T cells that are specialized in suppressing immune responses. Here we show that the arginine methyl transferase protein PRMT5 can complex with FOXP3 transcription factors in Tregs. Mice with conditional knock out (cKO) of PRMT5 expression in Tregs de...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Nagai, Yasuhiro, Ji, Mei Q., Zhu, Fuxiang, Xiao, Yan, Tanaka, Yukinori, Kambayashi, Taku, Fujimoto, Shigeyoshi, Goldberg, Michael M., Zhang, Hongtao, Li, Bin, Ohtani, Takuya, Greene, Mark I.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6375878/
https://ncbi.nlm.nih.gov/pubmed/30800128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00174
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