Linear Mixed Models for Association Analysis of Quantitative Traits with Next-generation Sequencing Data

We develop linear mixed models (LMM) and functional linear mixed models (FLMM) for gene-based tests of association between a quantitative trait and genetic variants on pedigrees. The effect of a major gene are modeled as a fixed effect, the contribution of polygenes is modeled as a random effect, an...

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Veröffentlicht in:Genet Epidemiol
Hauptverfasser: Chiu, Chi-yang, Yuan, Fang, Zhang, Bingsong, Yuan, Ao, Li, Xin, Fang, Hong-Bin, Lange, Kenneth, Weeks, Daniel E., Wilson, Alexander F., Bailey-Wilson, Joan E., Musolf, Anthony M., Stambolian, Dwight, Lakhal-Chaieb, M′Hamed Lajmi, Cook, Richard J., McMahon, Francis J., Amos, Christopher I., Xiong, Momiao, Fan, Ruzong
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6375753/
https://ncbi.nlm.nih.gov/pubmed/30537345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.22177
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